Welcome to the Clinical Criteria Page
This page provides the clinical criteria documents for all injectable, infused, or implanted prescription drugs and therapies covered under the medical benefit. Injectable oncology drug clinical criteria will not be posted on this page until mid-2019. The effective dates for using these documents for clinical reviews are communicated through the Provider notification process. Until implementation, providers should continue to access the clinical criteria for medications covered under the medical benefit through the traditional process.
The clinical criteria information is alphabetized in the table below.
Development of clinical criteria
All clinical criteria are developed to help guide clinically appropriate use of drugs and therapies and are reviewed and approved by the Pharmacy and Therapeutics (P&T) Committee. The P&T Committee is an independent and external committee including practicing physicians, pharmacists, and clinicians from leading academic medical centers and clinical practices with expertise in evidence-based medicine. All major clinical specialties are represented.
If you have questions or feedback, please use this email link.
| Clinical Criteria | Associated Medications (as applicable) | Document Number | Coding |
|---|---|---|---|
| Agents for Hereditary Angioedema | Cinryze, Haegarda, Berinert, Takhzyro, Berinert, Firazyr, Ruconest, Kalbitor | ING-CC-0034 | J0596, J0597, J0598, J1290, J1744, J0599, J3490, J3590, C9399 |
| Zoledronic Acid Agents | ING-CC-0019 | J3489 | |
| Akynzeo (fosnetupitant and palonosetron) for Injection | Akynzeo | ING-CC-0074 | J8655 |
| Aldurazyme (laronidase) | ING-CC-0025 | J1931, S9357 | |
| Alpha-1 Proteinase Inhibitor Therapy | Aralast, Glassia, Prolastin-C, Zemaira | ING-CC-0073 | J0256, J025, 7S9346 |
| Antihemophilic Factors and Clotting Factors | FEIBA, Novoseven RT, Hemofil-M, Koate-DVI, Monoclate-P, Advate, Afstyla, Helixate FS, Kogenate FS, Kovaltry, Novoeight, Nuwiq, Recombinate, Xyntha/Xyntha Solofuse, Adynovate, Jivi, Eloctate, Hemlibra, Obizur, Alphanate, Humate-P, Wilate, Vonvendi, Alphanine SD, Mononine, Bebulin, Profilnine SD, Benefix, Ixinity, Rixubis, Idelvion, Alprolix, Rebinyn, Coagadex, Corifact, Tretten, RiaSTAP, Fibryna/Fibryga | ING-CC-0065 | J7198, J7189, J7190, J7182, J7185, J7192, J7209, J7210, J7211, J7205, J7207, J7192, J7170, J7188, J7191, J7183, J7186, J7187, J7179, J7193, J7194, J7195, J7200, J7201, J7202, J7203, J7175, J7180, J7181, J7177, J7178 |
| Aristada Initio (aripiprazole lauroxil) | Aristada | ING-CC-0083 | C9035, J3490 |
| Benlysta (belimumab) | Benlysta | ING-CC-0028 | J0490 |
| Beta Interferons and Glatiramer Acetate for Treatment of Multiple Sclerosis | Avonex (interferon beta-1a), Plegridy (peginterferon beta-1a), Rebif (interferon beta-1a), Betaseron (interferon beta-1b), Extavia (interferon beta-1b), Copaxone (glatiramer acetate), Glatopa (glatiramer acetate) | ING-CC-0014 | J1595, J1826, J1830, J3490, Q3027, Q3028, S9559 |
| Botulinum Toxin | Botox, Xeomin, Dysport, Myobloc | ING-CC-0032 | 31573, 46505, 52287, 64612, 64616, 64617, 64642, 64643, 64644, 64645, 64646, 64647, 67345, 46505, 52287, 64611, 64612, 64615, 64616, 64617, 64642, 64643, 64644, 64645, 64646, 64647, 64650, 64653, J0585, J0586, J0587, J0588, S2340, S2341, J0585, J0586, J0587, J0588, S2340, S2341 |
| Brineura (cerliponase alfa) | ING-CC-0012 | J0567 | |
| Colony Stimulating Factor Agents | Neupogen, Nivestym, Zarxio, Neulasta, Fulphila, Leukine, Granix | ING-CC-0002 | 96377, J1442, J1447, J2505, J2820, Q5101, Q5108, Q5110, S9537 |
| Crysvita (burosumab-twza) | ING-CC-0081 | J0584 | |
| Denosumab agents | Prolia, Xgeva | ING-CC-0027 | J0897 |
| Dihydroergotamine (DHE) Injection | ING-CC-0052 | J1110 | |
| Dupixent (dupilumab) | Dupixent (dupilumab) | ING-CC-0029 | J3490, J3590 |
| Egrifta (tesamorelin) | Egrifta (tesamorelin) | ING-CC-0069 | J3490 |
| Elaprase (idursufase) | ING-CC-0024 | J1743, S9357 | |
| Entyvio (vedolizumab) | ING-CC-0071 | J1743, S9357 | |
| Enzyme Replacement Therapy for Gaucher Disease | Cerezyme (imiglucerase), Elelyso (taliglucerase), Vpriv (velaglucerase) | ING-CC-0051 | J1786, J3060, J3385, S9357 |
| Erythropoiesis Stimulating Agents | Aranesp (darbepoetin alfa), Epogen (epoetin alfa), Mircera (methoxy polyethylene glycol-epoetin beta), Procrit (epoetin alfa), Retacrit (epoetin alfa-epbx) | ING-CC-0001 | J0881, J0882, J0885, J0887, J0888, Q4081, Q5105, Q5106, S9537, EA, EB, EC |
| Exondys 51 (eteplirsen) | ING-CC-0044 | J1428 | |
| Fabrazyme (agalsidase beta) | ING-CC-0021 | J0180, S9357 | |
| Fuzeon (enfuvirtide) | ING-CC-0055 | J1324 | |
| GamaSTAN [(immune globulin (human)] | GamaSTAN. GamaSTAN S/D | ING-CC-0039 | 90281, J1460, J1560 |
| GnRH Analogs for the treatment of non-oncologic indications | Zoladex, Supprelin LA, Lupron Depot/Depot-Ped, Lupaneta Pack, Synarel Nasal Spray, Triptodur | ING-CC-0061 | C9399, J3490, J1675, J1950, J3315, J3316, J9202, J9217, J9218, J9225, J9226, J3490, S9560 |
| Growth hormone | Somatostatin: Genotropin, Humatrope, Norditropin, Nutropin AQ, Omnitrope, Saizen, Serostim, Zomacton, Zorbtive | ING-CC-0068 | J2940, J2941, Q0515, S9558 |
| H.P. Acthar Gel (repository corticotropin injection) | ING-CC-0004 | J0800 | |
| Human Parathyroid Hormone Agents | Tymlos (abaloparatide), Forteo (teriparatide) | ING-CC-0038 | J3490, J3110 |
| Hyaluronan Injections | Durolane, Euflexxa, Gel-One, Gen-Syn, GenVisc, Hyalgan, Hymovis, Monovisc, Orthovisc, Supartz/FX, Synvisc/-One, TriVisc, Visco-3 | ING-CC-0006 | J7318, J7320, J7321, J7322, J7323, J7324, J7325, J7326, J7327, J7328, J7329 |
| Immunoglobulins | Bivigam, Carimune NF, Cuvitru, Flebogamma DIF. Gammagard, Gammagard S/D, Gammaked, Gammaplex, Gamunex-C, Hizentra, Hyqvia, Octagam, Panzyga, Privigen | ING-CC-0003 | 90281, 90284, J1459, J1460, J1555, J1556, J1557, J1559, J1560, J1561, J1566, J1568, J1569, J1572, J1575, J1599, S9338 |
| Implantable and ER Buprenorphine Containing Agents | Probuphine, Sublocade | ING-CC-0030 | 11981, 11983, G0516, G0517, G0518, J0570, J3490, Q9991, Q9992 |
| Increlex (mecasermin) | ING-CC-0045 | J2170 | |
| Infertility Agents | Menopur, Follistim AQ, Gonal-f/RFF, Bravelle, Pregnyl, Novarel, Ovidrel, Cetrotide, Ganirelix, Lupron Depot, Crinone 8% gel, Endometrin, Prochieve 8% gel | ING-CC-0015 | J0725, J1950, J3355, J3490, J8499, S0122, S0126, S0128, S0132 |
| Injectable Hydroxyprogesterone for prevention of preterm birth | Makena | ING-CC-0053 | 99506, J1726, J1729, J7999, S9560 |
| Interleukin-1 Inhibitors | Arcalyst (rilonacept), Ilaris (canakinumab), Kineret (anakinra) | ING-CC-0064 | J2793, J0638, J3490, J3590 |
| Jetrea (ocriplasmin) | Jetrea (ocriplasmin) | ING-CC-0070 | 67028, J7316 |
| Kanuma (sebelipase alfa) | ING-CC-0037 | J2840 | |
| Krystexxa (pegloticase) | Krystexxa | ING-CC-0057 | J2507 |
| Lemtrada (alemtuzumab) | ING-CC-0009 | J0202 | |
| Lumizyme (alglucosidase alfa) | Lumizyme | ING-CC-0018 | J0221, S9357 |
| Mepsevii (vestronidase alfa) | ING-CC-0013 | J3397 | |
| Monoclonal Antibodies to Interleukin-17 | Cosentyx (secukinumab), Siliq (brodalumab), Taltz (ixekizumab) | ING-CC-0042 | C9399, J3490, J3590 |
| Monoclonal Antibodies to Interleukin-23 | Ilumya (tildrakizumab-asmn), Tremfya (guselkumab) | ING-CC-0050 | J1628, J3245 |
| Monoclonal Antibodies to Interleukin-5 | Cinqair (reslizumba), Fasenra (benralizumab), Nucala (mepolizumab) | ING-CC-0043 | J0517, J2182, J2786 |
| Monoclonal Antibodies to Interleukin-6 | Actemra (tocilizumab), Kevzara (sarilumab) | ING-CC-0066 | J3262, C9399, J3490, J3590 |
| Naglazyme (galsulfase) | ING-CC-0023 | J1458, S9357 | |
| Nulojix (belatacept) | Nulojix (belatacept) | ING-CC-0076 | J0485 |
| Ocrevus (ocrelizumab) | ING-CC-0011 | J2350 | |
| Octreotide Agents | Sandostatin, Sandostatin LAR Depot | ING-CC-0058 | J2353, J2354 |
| Onpattro (patisiran) | ING-CC-0082 | C9399, J3490 | |
| Orencia (abatacept) | ING-CC-0078 | J0129 | |
| Palynziq (pegvaliase-pqpz) | ING-CC-0077 | C9399, J3590 | |
| Prialt (ziconotide) | ING-CC-0040 | J2278 | |
| Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Inhibitors | Praluent (alirocumab), Repatha (evolocumab) | ING-CC-0010 | J3490, J3590 |
| Prostacyclin Infusion and Inhalation Therapy | Flolan (epoprostenol), Remodulin (treprostinil), Tyvaso (treprostinil), Veletri (epoprostenol), Ventavis (iloprost) | ING-CC-0067 | J1325, J3285, J7686, K0455, Q4074, S0155, S9347 |
| Radicava (edaravone) | Radicava (edaravone) | ING-CC-0049 | J1301 |
| Rituxan (rituximab) for Non-Oncologic Indications | ING-CC-0075 | J9312 | |
| Selected Injectable 5HT3 Antiemetic Agents | Aloxi injection | ING-CC-0056 | J2469 |
| Selected Injectable NK-1 Antiemetic Agents | Emend injection, Varubi injection, Cinvanti injection | ING-CC-0059 | J1453, J0185, J2797 |
| Selected Progestins | Crinone, Progesterone suppositories | ING-CC-0054 | N/A |
| Selective Vascular Endothelial Growth Factor (VEGF) Antagonists | Avastin, Mvasi (bevacizumab), Lucentis (ranibizumab), Eylea (aflibercept) | ING-CC-0072 | 67028, J2503, 67028, C9257, J9035, Q5107, 67028, J2778, 67028, J0178 |
| Soliris (eculizumab) | ING-CC-0041 | J1300 | |
| Spinraza (nusinersen) | Spinraza (nusinersen) | ING-CC-0048 | 96450, J2326 |
| Stelara (ustekinumab) | ING-CC-0063 | J3357, J3358 | |
| Strensiq (asfotase alfa) | Strensiq (asfotase alfa) | ING-CC-0079 | J3490 |
| Synagis (palivizumab) | ING-CC-0007 | 90378, S9562 | |
| Tegsedi (inotersen) | ING-CC-0084 | C9399, J3490 | |
| Testopel (testosterone subcutaneous implant) | ING-CC-0008 | 11980, S0189 | |
| Testosterone, Injectable | ING-CC-0026 | J1071, J3121, J3145 | |
| Trogarzo (ibalizumab-uiyk | ING-CC-0047 | J1746 | |
| Tumor Necrosis Factor Antagonists | Adalimumab agents (Humira, Amjevita, Cyltezo, Hyrimoz), Certolizumab pegol (Cimzia), Etanercept agents (Enbrel, Erelzi), Golimumab (Simponi, Simponi Aria), Infliximab agents (Remicade, Inflectra, Renflexis) | ING-CC-0062 | J0135, J0717, J1438, J1602, J1745, J3590, Q5103, Q5104, Q5109, S9359 |
| Tysabri (natalizumab) | ING-CC-0020 | J2323 | |
| Vimizim (elosulfase alfa) | ING-CC-0022 | J1322, S9357 | |
| Vivitrol (extended-release, injectable naltrexone) Injection | Vivitrol | ING-CC-0016 | J2315 |
| Xiaflex (clostridial collagenase histolyticum) injection | ING-CC-0017 | 20527, 26341, J0775 | |
| Xolair (omalizumab) | ING-CC-0033 | J2357 | |
| Zinplava (bezlotoxumab) | ING-CC-0046 | J0565 | |
| Intravitreal Corticosteroid Implants | Ozurdex (dexamethasone intravitreal implant), Retisert (Fluocinolone acetonide intravitreal implant), Iluvien (fluocinolone acetonide intravitreal implant | ING-CC-0031 | J7311 |
| Naltrexone Implantable Pellets | ING-CC-0036 | J3490, J7999 | |
| Duopa (carbidopa and levodopa enteral suspension) | ING-CC-0035 | J7340 |
